Regulation of RB Transcription In Vivo by RB Family Members
نویسندگان
چکیده
منابع مشابه
Distinct gene expression phenotypes of cells lacking Rb and Rb family members.
The study of tumor suppressor gene function has been aided by the creation of discrete gene alterations in the mouse. One such example can be seen in the study of tumor suppressor gene function in general and the retinoblastoma (Rb) tumor suppressor in particular. Because the phenotype of a cell is a direct reflection of the gene activity within that cell, a comprehensive analysis of changes in...
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The discovery of the retinoblastoma (RB-1) gene as a tumor suppressor that is disrupted in a majority of human cancers either via direct or indirect genetic alterations has resulted in increased interest in its functions and downstream effectors. Although the canonical pathway that links this tumor suppressor to human cancers details its interaction with the E2F transcription factors and cell-c...
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Gastric cancer is one of the most diffuse neoplastic pathologies in the world whose environmental and molecular causes, although deeply investigated, have not been completely clarified. Besides some well-established etiological factors, such as Helicobacter pylori and E-cadherin mutations, investigations on other possible causes gave contrasting results. Rb family proteins (including pRb/p105, ...
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The growth plate lacks vascular tissues and is solely composed of chondrocytes. The growth plate is composed of three layers, i.e., the resting, proliferating and hyper-trophic chondrocyte layers. The chon-drocytes in the resting and proliferating layers proliferate and then they uniformly maturate toward the diaphysis to become hypertrophic chondrocytes, which lose the ability to proliferate. ...
متن کاملRb binds c-Jun and activates transcription.
The retinoblastoma protein (Rb) acts as a critical cell-cycle regulator and loss of Rb function is associated with a variety of human cancer types. Here we report that Rb binds to members of the AP-1 family of transcription factors, including c-Jun, and stimulates c-Jun transcriptional activity from an AP-1 consensus sequence. The interaction involves the leucine zipper region of c-Jun and the ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2010
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00952-09